The original Cialis is an excellent product, and is one of the most popular ED drugs on the market.  The only down side is for some men is the fact that sexual encounters must be planned somewhat in advance, since it can take anywhere from 5 to 30 minutes for the effects to kick in.  This is just fine if you and your wife have scheduled to have sex at 8:00 every Wednesday night, but not so great if your sexy date decides to get frisky in the parking lot after dinner …and you’re not prepared.

No man wants to say, “Can we hold this thought for about 30 minutes until my pill kicks in.” That’s an embarrassing situation for both the man and woman, and could definitely kill the mood.  It could even be a deal breaker during a first time sexual encounter, which is so important in a new relationship.  Daily Cialis allows a man to achieve an erection whenever he needs it without any “down-time,” so to speak.  Since the active ingredient “tadalafil” is already in your system, you are ready to go any time, any place.  This allows a man to recover his spontaneity, and his confidence, which is vital to a healthy sex life.

Luckily, this game-changing product is available online through AccessRx.com.  There is no reason for anyone to even know that you’re taking Daily Cialis.  Your woman will never see you take it, and she will never again have to wait for any pill to kick in before you can become intimate.  Get in the game with Daily Cialis where you can purchase discreetly at AccessRx, and get back the stamina that you need to make your woman keep coming back for more.

By Brian Bujdos

The New York Times reports that worldwide drug-related spam has fallen by as many as 50 billion messages per day thanks to a crackdown on infamous Russian spammer Igor A. Gusev. The huge 20 percent drop off may have gone essentially unnoticed by most people because of the widespread use of spam filters.

Companies that monitor the Internet, both in the U.S. and abroad, noted they saw a substantial decrease in spam beginning last week.  Antivirus company Kaspersky Lab, based in Moscow, noted that the percentage of mass emails (spam) in the United States that contained drug-related advertising was 65 percent near the end of October. That number has fallen to 41 percent in the beginning of November, the company said.

Gusev was reportedly heavily involved in the operations of SpamIt.com, a website believed to be a crux in the proliferation of drug-related spam. In fact, a nonprofit organization named Spamhaus, which monitors global spam, listed SpamIt.com and its partners/affiliates as the world’s largest sponsor of spam.

According to United Press International (UPI), Gusev also utilized a partner website called Glavmed.com to propagate spam. Gusev’s lawyer said he was not involved with sending email spam through SpamIt.com or any website.

However, SpamIt.com ceased operations on Sept. 27, six days after the Russian investigation into Gusev began. The drop in worldwide spam coincided directly with the website’s closure, according to monitoring agencies. Gusev is apparently not in Russia at this time. Russian authorities are seeking to speak with him.

Although no formal charges have been filed against Gusev, the investigation continues, and Russian authorities have removed several hard drives, flash cards and laptops from his place of residence. The New York Times reports that specific, computer crime-related charges may follow. At the very least, Russian authorities say Gusev has illegally operated a pharmacy without a license, and failed to register a business.

It seems that American Internet security experts are calling the Russian crackdown on Gusev and his partners an important, groundbreaking development that reverses the country’s trend of turning its back on cyber crime. Some have even accused the Russian government of being in some way partnered with Russian spammers, perhaps because they were profiting from the mass emails, or were utilizing the tech savvy of the spammers for other reasons.

However, Russian President Dmitri A. Medvedev has sought to expand and legitimize the Russian Internet industry. Earlier this year, he and his cabinet visited California to meet with Silicon Valley executives. Perhaps it is no coincidence that SpamIt.com ceased operations about two weeks before California Governor Arnold Schwarzenegger and his delegation reciprocate their visit to Moscow on Oct. 10.

The predominately male sex hormone testosterone is 20 times more prevalent in men than women, giving the widely believed notion that men want sex all the time. Not really surprising considering how much more testosterone men have than women. The physical act of sex considerably eases the testosterone pressure men experience constantly.

Here are some updates on solutions for the most common male sexual issues, because many men don’t know enough about their sexuality and bodies, even though it is a biological reality that men have a bigger issue about sex than women.

The issue at hand

Urologists and sexual therapists treat hundreds of cases of erectile dysfunction a month, in which the most common treatment methods include using medications such as Viagra and Cialis. Many men choose to buy these medications online, due to its discretion and convenience. However, learning how to buy Cialis or Viagra online is important and it is critical to order only FDA-approved medications from a secure online pharmacy.

ED is defined as a condition when a man is unable to achieve or maintain an erection suitable for successful sexual intercourse. Experts say this issue accounts for most sexual issues that men encounter. It’s a “use it or lose it” scenario sexologists like to tell their patients. An excess of masturbation or sex may actually help against erectile dysfunction, which goes against popular belief. Old men are expected to have a decreased libido due to drops in testosterone levels, but it seems younger men are joining the older ones for various reasons. Treating ED is a sensitive subject, and in recent studies, men are starting to favor Cialis over its competitor Viagra.

At the University of Tampere in Finland, researchers observed that men having sex less than once a week also had twice the amount of problems with erectile dysfunction, as compared to those who had sex more than once per week.

Dr. V.K. Wadia, a sexual medicine consultant at the Bhagat Hospital says, “Your brain desires something, and arousal takes place”. Once the arousal takes place, blood flow increases to the penis, causing the erection. “Erection is a mind and body game,” he adds. Issues such as stress, performance anxiety, or psychological reasons and physical disease, can cause the natural erection process to fail.

Other Causes for ED
Heart disease, obesity, spinal injury, diabetes, multiple sclerosis, Parkinson’s disease, high blood pressure, and other diseases can unfortunately cause the failure of an erection.

In addition, the development of plaque in the penile arteries can affect the process of getting an erection due to the above diseases. A Mayo Clinic study shows there is an 80% risk increase that men who have erectile dysfunction will eventually develop heart disease, as compared to men without heart disease. They surmise that the plaque that clogs arteries in the heart may actually start with the smaller penile arteries that get clogged and cause the ED.

Other factors can also affect men’s performance in bed. Alcohol, smoking, substance abuse, and some anti-depressants can all be contributors. Even a lot of bicycling can cause ED, believe it or not. The bike seat can compress nerves and stem blood flow to the penis over a period of time.

Think you have performance anxiety or a psychological problem? If you get a morning erection – healthy males normally get an erection in their sleep 3 to 4 times a week – then you should be fine. If you don’t, then your incapacity for erections can be resolved by treating the underlying problem before it gets worse. You should speak with your doctor if you feel you may have erectile dysfunction, whether it is caused by physical problems or psychological ones. Your doctor can either prescribe you an ED medication (which can also be bought online), provide another course of action, or give you a referral to another specialist who may be able to help your situation.

The main thing is to overcome any urges to ignore the problem. Simply step forward and address your ED issues, because solutions are available.

Most people wouldn’t want to be in the same room as the most venomous spider in the world. But one day, people may voluntary ask to consume toxin from the venom of the deadly Brazilian wandering spider.

It turns out that, when bitten by the wandering spider, some men suffer painful erections that last more than 4 hours and sometimes lead to permanent damage to the penis. This led researchers to isolate the Tx2-6 toxin in the spider’s venom, and inject it into rats to measure potential improvements in erectile function.

Doctors at the Medical College of Georgia in Augusta radioactively labeled and injected a purified form of the toxin into rats that suffered from high blood pressure and severe erectile dysfunction. The researchers found that the toxin had a very positive reaction in the rats. Results showed improved levels of nitric oxide, which led to penile relaxation and erections.

Viagra, Cialis and Levitra all work similarly to the isolated toxin, in that they all enhance the effects of nitric oxide, a chemical that relaxes smooth muscles in the penis during sexual stimulation and allows increased blood flow.

“The concept that a venom can have an effect on erection is highly plausible,” said Dr. Arnold Melman, chief of urology at Montefiore Medical Center in New York City. “This is very interesting and exciting, but also very early.”

Various doctors lauded the work.

“We do need more research,” added lead researcher Kenia Pedrosa Nunes, Ph.D., Medical College of Georgia. “I’m sure it can be a pharmacological tool that may one day be able to help patients who cannot take Viagra.”

Topical ED Ointment Shows Promise

Many have tried, but all have failed. Apparently, it’s pretty hard to formulate and perfect a topical ointment for erectile dysfunction.

Researchers at Yeshiva University in New York, however, may be on to something. They are testing a drug-delivery system that consists of nanoparticles – each smaller than a grain of pollen – in mice. And, based on the positive results, researchers will be performing further testing on the ED ointment.

If it comes to market, this topical Viagra should prove to be a safer and more effective ED therapy with less side effects. Who knows, depending on how the FDA views the safety of the product, and whether or not they want the ointment to be in the hands of the general public, the product could potentially be sold over the counter.

The groundbreaking research tested nanoparticles encapsulating nitric oxide to see if they can carry tiny payloads of various drugs or other medically useful substances and successfully release them in a manner that is controllable and sustainable. The study found that Einstein nanoparticles, which have been shown to penetrate the skin, can allow the targeted delivery of compounds that treat ED. This essentially eliminates the systemic side effects caused by the three current, FDA-approved pill medications.

“Most of the animals, nearly 90 percent, showed a response to treatment with the nanoparticles,” says co-author Joel M. Friedman, M.D., Ph.D., professor of physiology & biophysics and of medicine. And, response time to the nanoparticles was very quick, just a few minutes. Current ED pill medications do not begin to work to their full potential for at least 20 to 30 minutes.

Clinical studies on humans could begin in a few years if nanoparticle studies on animals continue to progress as expected. However, as investigators cautioned, the time from a proof-of-concept trial in animals to approved use in humans could be at least a decade.

Although studies of the spider venom treatment and nanoparticle treatment are still in their infancy, middle-aged men who currently do not suffer from ED complications may have a failsafe in case they ever do.

Brian Bujdos

Learning you have Erectile Dysfunction is not an easy discovery – finding ways to treat it is even harder. Searching the internet for ED medications is a step many men initially take, but you need to know what to look out for before you buy dangerous misleading products.

Medications such as Cialis, Levitra or Viagra are leading prescription medications that treat Erectile Dysfunction, but be careful when trying to find inexpensive herbal alternatives to these products online. Do not think that using herbal erectile dysfunction supplements are always safer than ED medicines, because they are not.

If you are looking for an alternative to Viagra or Cialis, then a simple search would lead you to hundreds of herbal alternatives. These are being promoted as a safe alternative because they are all-natural. However, using products that are supposedly “natural” can pose more risk to your health because in the first place they do not follow strict guidelines provided by the U.S. Food & Drug Administration (FDA). Just recently, two herbal dietary supplement products have been recalled due to containing Tadalafil and Sildenafil, which are found in Viagra and Cialis. So this is a clear example of why these treatments are not safe and should be watched over with caution.

There is no supplement certified to be as effective and safe as FDA-approved erectile dysfunction drugs. If you see these supplements being advertised and marketed on the internet, take them at your own risk. Most of these herbal supplements are adulterated and do not show the ingredients, as well as the possible negative effects they might cause. There is not an FDA-recommended safe dosage, so there is always a chance of overdosing.

If you are experiencing the symptoms of erectile dysfunction, such as difficulty in achieving and maintaining an erection, then the best thing you can do to help yourself is to consult with a health professional who can diagnose your condition. Your doctor will prescribe an FDA-approved erectile dysfunction medication if he thinks it is the best solution for you. Along with discussing erectile dysfunction with your doctor, you could also go online and discuss ED in forums. One active forum is at edguider.com, where men can discuss erectile dysfunction and treatments for it.

Most people who take medications for Erectile Dysfunction are also taking other medicines that may interact negatively with them.  Imagine the havoc it can cause your health if you take herbal supplements that should not be ingested while taking other medications.

Again, herbal supplements may be promoted as natural products, but it does not mean they are safe for you. There are supplements that can cause serious damage to bodily organs, and you do no want to cause yourself harm by taking cheap herbal alternatives.

Edguider.com offers men who suffer from Erectile Dysfunction a place to vent and share their experiences about anything related to ED. They also have great comparison charts for Viagra, Cialis and Levitra, where men can choose and review pharmacies, such as which American online pharmacy is right for them.

So before jumping to conclusions or buying the first herbal option you see online, research and get the facts in order to take the safest route.

Guest Author Post by http://www.edguider.com, a great website that researches and reviews Viagra, Cialis and Levitra

Many men have asked their doctors which erectile dysfunction medication works best, and which one has the least amount of side effects. Hopefully their doctors answered correctly…

According to a recent study by the Agency for Healthcare Research and Quality (part of the department of Health and Human Services), all three FDA-approved medications for ED work with equal effectiveness, and none of them appear to be more harmful (in terms of adverse events/side effects).

The reason for this may be that all three ED medications work in a similar way as PDE-5 inhibitors.

To borrow a quote…

“The PDE-5 inhibitors are all effective, just not one over any of the others,” said Matthew Cantrell, assistant clinical professor at the University of Iowa College of Pharmacy and clinical pharmacy specialist at the Iowa City VA Medical Center. “This pretty much represents maintenance of the status quo in ED treatment. Product selection is still up to the prescriber and patient and specific factors such as price and formulary status.”

Even the prices of the three ED medications are very similar. On AccessRx, for example, 10 Viagra pills and 10 Levitra pills are $199. Ten Cialis pills are $219, but Cialis works for up to 36 hours while Viagra and Levitra work 4 to 5 hours. So price appears to be a push too. Many patients choose to buy the highest-dose of each pill and cut them in half with a pill splitter to save money.

The overview of the study also details the fact that side effects for each of the three pills were found to be about the same in terms of prevalence and intensity.

Different ED medications will have slightly different effects for each patient due to the different ingredients in each of the three medications. Patients at AccessRx are able to order more than one medication in each transaction and can try all three (Viagra, Cialis, Levitra) conveniently.

In fact, AccessRx is working on putting a trial pack together with three pills for each ED medication. Check back in the coming weeks for the debut of this new item.

Brian Bujdos

You may have heard Los Angeles Dodgers slugger and superstar Manny Ramirez was suspended earlier this week by Major League Baseball.

As if the sport didn’t have enough cheaters, right? These boys just won’t let the steroid era end. Home run masher Mark McGuire won’t talk about it, A-Rod recently admitted he’s a cheat, and now Manny Ramirez has further tarnished a sport that was already a thick, gunky brown.

Apparently Ramirez will lose a hefty $7.7 million in pay to miss the 50 games that will keep him out until the July 4th weekend. (I wonder if the Dodgers and MLB will donate the money to charity… … … pockets of laughter… … …)

Manny Has ED?

The one item that we found interesting was that at least one credible source said that the illegal substance that was consumed by Ramirez was for erectile dysfunction. And immediately we wondered, since Manny has some time on his hands, will we see him on Sunday Night Baseball later this season — not hitting home runs at Chavez Ravine, but talking about “when the moment is right” for Viagra?

He probably wouldn’t fit in one of the Cialis dueling tubs, not with all of those steroid-ridden muscles, right? And Levitra seems akin to a small-market team in the world of ED medications, so our money is on Manny signing a lucrative ($7.7 million) contract with Pfizer, which manufactures Viagra. What a perfect fit. Rafael Palmeiro, a former spokesperson for Viagra, went down in flames in a similar steroid scandal when he was suspended in 2005.

If anything, this latest Manny Ramirez debacle makes us realize that Viagra, erectile dysfunction and Major League Baseball may be more intertwined than it seems. 

HCG the Culprit?

As the jokes continue to surface, it appears that the actual substance in question for Ramirez is HCG. According to the Los Angeles Times, “A high-ranking sports doping authority said HCG could legitimately be prescribed for a man who does not naturally produce enough testosterone, but BALCO founder and convicted steroid dealer Victor Conte said it is often used to replenish testosterone levels at the end of a cycle of steroid treatments… HCG is one of dozens of substances prohibited under baseball’s policy.”

HCG is not an ingredient in Viagra, Cialis or Levitra. Although these three FDA-approved ED meds are not banned by most sports leagues and associations, studies are underway, believe it or not, to see if they should be banned. Unsurprisingly (think about it) they can help blood flow in all parts of the body, and some studies indicate these ED medications provide an unfair advantage to athletes who compete at high altitudes.

We may see Viagra, Cialis and Levitra on the banned substance list yet. In which case Manny Ramirez would apparently be left with no options for his ED.

Brian Bujdos

If you have taken FDA-approved erectile dysfunction (ED) medications, or have considered requesting a prescription, you may be familiar with some of the side effects included in the official patient information pamphlet.

A few of the most serious of these side effects deal with vision.

However, a recent study published in the April, 2009 edition of Archives of Ophthalmology revealed that when 212 men took Viagra and Cialis every day for three months, there were no reported changes in visual function, signs of retina damage or intraocular pressure. Likewise, after daily use for 6 months, no vision loss or impairment of any sort was reported in 155 men who continued to take the medications.

2005 Labeling Change

After Viagra and Cialis were put on the market, the FDA stated that there were a “small number” of reports of vision loss, which prompted a labeling change on packages of Viagra, Cialis and Levitra.

Yet, the FDA said “it is not possible to determine whether these oral medicines for erectile dysfunction were the cause of the loss of eyesight or whether the problem is related to other factors such as high blood pressure or diabetes, or to a combination of these problems.”

You can access patient information for Viagra, as well as patient information for Cialis on our website.

ED Medications and the Retina

The authors of the study, as quoted in USA Today, stated that “PDE5 inhibitors can exert direct effects on the retina, and such effects probably account for many of the visual side effects… that have been reported.” Some men have rarely reported that their vision appears to have a bluish tint, or that they are more sensitive to light, after taking ED medications.

Men who have ever had severe loss of vision, which might reflect a prior episode of non arteritic ischemic optic neuropathy (NAION), should share this information with their doctor, as such patients are at an increased risk of developing NAION again.

Again, these types of side effects are rare. In the event you have side effects affecting your vision, speak with your doctor.

Summary of Study

The authors of the above Archives of Ophthalmology study concluded that, with regard to the vision of study participants, “results indicate that there is no cumulative damage or effect of clinical significance for either 5 milligrams of tadalafil (Cialis) or 50 milligrams of sildenafil (Viagra) taken daily for six months.”

This is encouraging news for a very specific study carried out by professional ophthalmologists.

A summary of the study has been provided by Reuters news organization.

Brian Bujdos

Has erectile dysfunction (ED) advertising become intrusive enough to affect our “normal” daily lives? Depends who you ask.

Consumer Reports states that manufacturers Pfizer (Viagra), Lilly (Cialis) and GlaxoSmithKline (Levitra) spent more than $300 million in advertising their products in 2007 alone. Cialis ad spending was up to $152 million in 2007, more than 250 percent over 2006.

Considering that more than 18 million prescriptions were written for these drugs, and that combined sales eclipsed $3.7 billion, you can see why the manufacturers have casting calls for new commercials almost every day.

This is big money we’re talking about. But when does it go too far? Due simply to the demographics of certain TV audiences, the manufacturers focus their efforts in specific areas — especially sporting events.

Can parents watch a Sunday afternoon of NFL football with their kids, or sit through an evening watching “America’s Game,” without their own little sluggers asking why the guy in the commercial needs medicine?

You don’t exactly have to scour the internet to find media articles and blog posts calling for a reprieve from ED. Personally, I’ve gotten used to these commercials (don’t we fast-forward our DVR through them all now anyway?) and I don’t have kids. So, I may not be the best person to ask.

But on the other hand, many things that kids are exposed to these days (not the least of which are low-lifes at school or even many grown-up versions in the adult general public) are a lot worse.

Many things need to be explained to kids these days, and ED may seem like a walk in the park when it comes to drugs and other things we need to help our youth steer clear of. But, when it comes down to it, there’s always a non-profit we can turn to for a little guidance, right?

In this case, it’s the Pharmaceutical Research and Manufacturers of America, and their 16 Guiding Principles for Direct to Consumer Advertising. These guys are the “policy setters” and “watchdogs” over their industry.

For instance, No. 16 of their guiding principles states: “In terms of content and placement, DTC television and print advertisements should be targeted to avoid audiences that are not age appropriate for the messages involved. In particular, DTC television and print advertisements containing content that may be inappropriate for children should be placed in programs or publications that are reasonably expected to draw an audience of approximately 90 percent adults (18 years or older).”

Talk about ambiguous, huh? What is considered “content that may be inappropriate for children?” Good question. It is something that people all over the world debate. If you think you have the answer, feel free to leave a comment.

Right now, I need to go set my DVR.

Brian Bujdos

For a while there, it looked like we would never see another drug manufacturer challenge the highly competitive market for erectile dysfunction (ED) drugs. The two big dogs, Viagra and Cialis, control 90 percent of the annual revenue for the $3.7 billion market. Levitra controls the rest.

Now, within a matter of weeks, two new potential ED drugs have come out of the woodwork. This blog highlighted Rexahn’s drug named Zoraxel late last month. And now, VIVUS (which also provides prescription urethral suppository Muse, as well as Actis, a latex constriction loop) has announced a second Phase 3 trial for their ED drug named Avanafil.

It has been more than five years since the FDA approved a drug for ED, and that was for Cialis back in November of 2003. It has taken Cialis five years, but its $1.44 billion in annual worldwide sales is now approaching Viagra’s $1.93 billion.

All things being equal, Levitra is generally considered to be just as effective as Viagra and Cialis, but it seems Levitra/Bayer/Glaxo Smith-Kline are not willing to ante up to try to take a bigger slice of the market. They seem happy with their $300+ million annual return.

Viagra has been around for more than 10 years, has the history and tradition of a grizzled veteran. Cialis lasts for up to 36 hours and is a rising star.

So one has to ask:  How much room is there for another new kid on the block? Sure, sheer curiosity may provide a quick buck or two, but how many of the 25+ million men who have used Viagra, most with success, will even waver? Hard to say, but the number is sure to grow when the Viagra patent for active ingredient Sildenafil Citrate expires in March, 2012.

At that point, generic versions are sure to find a way to market, and once they are FDA-approved, prices for ED meds are sure to drop quite a bit — which should make fun in the bedroom more economical.

Although Zoraxel and Avanafil are probably at least a couple years away from the market, their introduction could shake things up depending on how they are priced, and what new benefits they provide. As far as Avanafil is concerned, here is the scoop from the VIVUS press release concerning Phase 3 trials for diabetics.

“Early data suggest that avanafil may provide a fast-acting therapy with a short half-life, which, if approved, may represent a noteworthy advance for the millions of men living with ED and searching for new options.”

That’s the question, how many men are searching for new options. There are already three proven medications, and who needs one that doesn’t last as long? Success for Avanafil may depend on how quickly it works. The other ED meds can start working in about a half an hour, sometimes even sooner. You can compare Viagra, Cialis and Levitra here.

The success of Zoraxel may hinge on the fact it apparently may have less side effects. Every pill needs a plug, and without it, success is not a given. Just ask Levitra/Bayer. They have no gimmick, and they’ve been lapped like a race car equipped with a V-6.

Considering how much money it takes to get these medications to market, there will be lots of pressure for success from investors, to say the least. It will be interesting to see how these ED medications attempt to set themselves apart from the rest. And considering the competition, they might need more money for marketing than they did for research and development.

Brian Bujdos